Make it Count
Countable PCR delivers absolute single-molecule counting — at least 10× the sensitivity of digital PCR, with dynamic range and accuracy nothing else achieves.
One platform. Endless flexibility.
Countable PCR Core Bundle
A familiar PCR workflow with single-molecule DNA counting — superior sensitivity and linear performance across a wide dynamic range.
≥10x
More sensitive than digital PCR.
6-log
Linear at R² = 0.9999.
RNA Module
One-step RT + amplification for accurate RNA counts.
Assay Services
Proof-of-concept studies, sample to data.
Countable 4
Up to 4 targets, 96 samples per run, automated analysis and QC.
Control Software
21 CFR Part 11–ready instrument control, audit trails, signed reports.
How the platforms compare.
Quantification, range, precision, and sensitivity — side by side.
Quantitative PCR
qPCR
Digital PCR
dPCR
Single-molecule counting PCR
Quantification method
Real-time, kinetics-based
Relative to standard curve
End-point, binary signal
Poisson correction needed
Direct single-molecule counting
One molecule per compartment
Dynamic range
10¹–10⁷
Linearity-dependent
10⁴–10⁸
Narrow range
6-log range
Broadest, highest precision
Precision
Low
50-100% CV
Moderate
-10% CV
High
<1% CV
Sensitivity
Limited
>1% VAF
High, with effort
~0.03% VAF
Highest
0.004% VAF
Quantitative PCR
qPCR
Quantification method
Real-time, kinetics-based
Relative to standard curve
Dynamic range
10¹–10⁷
Linearity-dependent
Precision
Low
50-100% CV
Sensitivity
Limited
>1% VAF
Digital PCR
dPCR
Quantification method
End-point, binary signal
Poisson correction needed
Dynamic range
10⁴–10⁸
Narrow range
Precision
Moderate
-10% CV
Sensitivity
High, with effort
~0.03% VAF
Single-molecule counting PCR
Quantification method
Direct single-molecule counting
One molecule per compartment
Dynamic range
6-log range
Broadest, highest precision
Precision
High
<1% CV
Sensitivity
Highest
0.004% VAF
The technology in 90 seconds
A short introduction to how single-molecule counting works — and why it changes what you can measure.
DNA linkage analysis across PCR technologies
When more than one molecule shares a compartment, you can't tell a complete molecule from partials. Countable PCR isolates one molecule per compartment — so the optical signature tells you exactly what's there.
Multiple molecules in a single partition
A complete molecule — or partial molecules sharing one compartment. You can't tell which.
One molecule per compartment
Count anything.
See what becomes measurable when counting is precise and effortless.
Where precision counts
Cell & gene therapy
Genome integrity, titer, and VCN — from ITR to ITR in a single run.
Oncology & liquid biopsy
Rare variants at 0.004% VAF in a high wild-type background.
Molecular diagnostics
Absolute quantification you can standardize across sites.
Viral genome integrity
Distinguish complete genomes from partials with linkage.
Genome editing QC
Quantify edits and unintended events with single-molecule clarity.
Fusion detection
Resolve fusion transcripts directly, no sequencing required.
See Countable PCR run on your samples — typical turnaround in days.
A new class of measurement
Resolving linkage at the level of the individual molecule unlocks measurements that were impossible or impractical with PCR, dPCR, or NGS.
See the rarest signal
Detect and quantify variants down to 0.004% VAF — sensitivity dPCR and NGS can't reach.
See the rarest signal
Detect and quantify variants down to 0.004% VAF — sensitivity dPCR and NGS can't reach.
See the rarest signal
Detect and quantify variants down to 0.004% VAF — sensitivity dPCR and NGS can't reach.
See the rarest signal
Detect and quantify variants down to 0.004% VAF — sensitivity dPCR and NGS can't reach.
Single-molecule precision. Make it count